Interactions of human monoclonal and polyclonal antiphospholipid antibodies with serine proteases involved in hemostasis
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چکیده
منابع مشابه
Interactions of human monoclonal and polyclonal antiphospholipid antibodies with serine proteases involved in hemostasis
OBJECTIVE To characterize the interaction between procoagulant and/or anticoagulant serine proteases and human monoclonal IgG antiphospholipid antibodies (aPL) and polyclonal IgG derived from patients with the antiphospholipid syndrome (APS). METHODS Five human monoclonal IgG with small differences in their sequences were tested for binding to protein C, activated protein C, plasmin, factor V...
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It is generally accepted that the major autoantigen for antiphospholipid antibodies (aPL) in the antiphospholipid syndrome (APS) is beta(2)-glycoprotein I (beta(2)GPI). However, a recent study has revealed that some aPL bind to certain conformational epitope(s) on beta(2)GPI shared by the homologous enzymatic domains of several serine proteases involved in hemostasis and fibrinolysis. Important...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2011
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.30525